Impaired intracortical inhibition in the primary somatosensory cortex in focal hand dystonia
Identifieur interne : 002802 ( Main/Exploration ); précédent : 002801; suivant : 002803Impaired intracortical inhibition in the primary somatosensory cortex in focal hand dystonia
Auteurs : Yohei Tamura [États-Unis, Japon] ; Masao Matsuhashi [États-Unis] ; Peter Lin [États-Unis] ; Bai Ou [États-Unis] ; Sherry Vorbach [États-Unis] ; Ryusuke Kakigi [Japon] ; Mark Hallett [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-03-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Auditory Perception (physiology), Disability Evaluation, Discrimination, Dystonia, Dystonia (physiopathology), Evoked Potentials (physiology), Female, Hand, Hand (physiopathology), Humans, Male, Middle Aged, Nervous system diseases, Neural Inhibition (physiology), Neural Pathways (physiopathology), Severity of Illness Index, Somatosensory Cortex (physiopathology), Somatosensory cortex, Somatosensory evoked potential, Thalamus (physiopathology), Time Perception (physiology), Visual Perception (physiology), focal hand dystonia, somatosensory‐evoked potential, somesthetic temporal discrimination, surround inhibition.
- MESH :
- physiology : Auditory Perception, Evoked Potentials, Neural Inhibition, Time Perception, Visual Perception.
- physiopathology : Dystonia, Hand, Neural Pathways, Somatosensory Cortex, Thalamus.
- Adult, Disability Evaluation, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Somesthetic temporal discrimination (STD) is impaired in focal hand dystonia (FHD). We explored the electrophysiological correlate of the STD deficit to assess whether this is due to dysfunction of temporal inhibition in the somatosensory inhibitory pathway or due to dysfunction in structures responsible for nonmodality‐specific timing integration. Eleven FHD patients and 11 healthy volunteers were studied. STD threshold was investigated as the time interval required for perceiving a pair of stimuli as two separate stimuli in time. We also examined the somatosensory‐evoked potential (SEP) in a paired‐pulse paradigm. We compared STD threshold and recovery function of SEP between the groups. STD thresholds were significantly greater in FHD than in healthy volunteers. The amount of P27 suppression in the 5 ms‐ISI condition was significantly less in FHD. It was also found that the STD threshold and P27 suppression were significantly correlated: the greater the STD threshold, the less the P27 suppression. Significantly less suppression of P27 with a lack of significant change in N20 indicates that the impairment of somatosensory information processing in the time domain is due to dysfunction within the primary somatosensory cortex, suggesting that that the STD deficit in FHD is more attributable to dysfunction in the somatosensory pathway. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21870
Affiliations:
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We explored the electrophysiological correlate of the STD deficit to assess whether this is due to dysfunction of temporal inhibition in the somatosensory inhibitory pathway or due to dysfunction in structures responsible for nonmodality‐specific timing integration. Eleven FHD patients and 11 healthy volunteers were studied. STD threshold was investigated as the time interval required for perceiving a pair of stimuli as two separate stimuli in time. We also examined the somatosensory‐evoked potential (SEP) in a paired‐pulse paradigm. We compared STD threshold and recovery function of SEP between the groups. STD thresholds were significantly greater in FHD than in healthy volunteers. The amount of P27 suppression in the 5 ms‐ISI condition was significantly less in FHD. It was also found that the STD threshold and P27 suppression were significantly correlated: the greater the STD threshold, the less the P27 suppression. Significantly less suppression of P27 with a lack of significant change in N20 indicates that the impairment of somatosensory information processing in the time domain is due to dysfunction within the primary somatosensory cortex, suggesting that that the STD deficit in FHD is more attributable to dysfunction in the somatosensory pathway. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Maryland</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Tamura, Yohei" sort="Tamura, Yohei" uniqKey="Tamura Y" first="Yohei" last="Tamura">Yohei Tamura</name></region><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name><name sortKey="Lin, Peter" sort="Lin, Peter" uniqKey="Lin P" first="Peter" last="Lin">Peter Lin</name><name sortKey="Matsuhashi, Masao" sort="Matsuhashi, Masao" uniqKey="Matsuhashi M" first="Masao" last="Matsuhashi">Masao Matsuhashi</name><name sortKey="Ou, Bai" sort="Ou, Bai" uniqKey="Ou B" first="Bai" last="Ou">Bai Ou</name><name sortKey="Vorbach, Sherry" sort="Vorbach, Sherry" uniqKey="Vorbach S" first="Sherry" last="Vorbach">Sherry Vorbach</name></country><country name="Japon"><noRegion><name sortKey="Tamura, Yohei" sort="Tamura, Yohei" uniqKey="Tamura Y" first="Yohei" last="Tamura">Yohei Tamura</name></noRegion><name sortKey="Kakigi, Ryusuke" sort="Kakigi, Ryusuke" uniqKey="Kakigi R" first="Ryusuke" last="Kakigi">Ryusuke Kakigi</name><name sortKey="Tamura, Yohei" sort="Tamura, Yohei" uniqKey="Tamura Y" first="Yohei" last="Tamura">Yohei Tamura</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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